Ferrer and Murray through

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Updated: August 30, 2012

Spanish fourth seed David Ferrer, Argentine seventh seed Juan Martin Del Potro and US ninth seed John Isner won their openers at the US Open on Wednesday.

The US Open has seen nine men’s comeback triumphs from two sets down in the first round, matching the record from 1989, including Serbian ninth seed Janko Tipsarevic’s 4-6, 3-6, 6-2, 6-3, 6-2 victory over Frenchman Guillaume Rufin.

And Australian Lleyton Hewitt, the 2001 US Open champion, reached the second round by dispatching Germany’s Tobias Kamke 4-6, 6-2, 6-1, 6-4.

Ferrer, who became the top seed in his quarter of the draw when compatriot Rafael Nadal pulled out with knee problems, defeated South Africa’s Kevin Anderson 6-4, 6-2, 7-6 (7/3).

Ferrer, whose best Grand Slam showing was a 2007 US Open semifinal run, booked a second-round match against Dutch qualifier Igor Sijsling, who beat Spain’s Daniel Gimeno-Traver 7-5, 6-3, 6-4.

Isner, the top American hope to end a nine-year US men’s Grand Slam title drought, struggled to subdue Xavier Malisse 6-3, 7-6 (7/5), 5-7, 7-6 (11/9).

Del Potro, the 2009 US Open winner, advanced over France’s Florent Serra 6-4, 7-6 (7/4), 6-4.

Andy Murray made light work of Croat Ivan Dodig, dispatching him in 3 sets, 6-2, 6-1, 6-3.

In the ladies draw, British teen Laura Robson ended the singles career of three-time US Open champion Kim Clijsters on Wednesday with an emotional 7-6 (7/4), 7-6 (7/5) victory in the second round.

Clijsters, 29, made her final bow on the same court where she won her first Grand Slam title in 2005 and followed it up with crowns in 2009 and 2010. She had said she was leaving the sport for more time as a wife and mother.

Robson, will next face Chinese ninth seed Li Na, who dispatched Australia’s Casey Dellacqua 6-4, 6-4, in 87 minutes.

World No 1 Victoria Azarenka, this year’s Australian Open champion, reached the third round while defending champion Samantha Stosur and third seed Maria Sharapova, the reigning French Open champion, advanced with ease as well.

Reigning Australian Open champion Azarenka reached the third round by defeating Belgian qualifier Kirsten Flipkens 6-2, 6-2 in only 65 minutes for her 50th match victory of the season.

Azarenka, who has reached the last eight in every Grand Slam event except the US Open, will next face Chinese 28th seed Zheng Jie, who beat Slovakian qualifier Magdalena Rybarikova 6-3, 6-1.

Australian seventh seed Stosur took an hour to beat Romanian qualifier Edina Gallovits-Hall 6-3, 6-0 to reach a third-round date with US 31st seed Varvara Lepchenko.

Russian third seed Sharapova ripped Spain’s Lourdes Dominguez Lino 6-0, 6-1 to book a third-round match against 21-year-old US wildcard Mallory Burdette, ranked 252nd, who advanced with a 6-2, 6-4 victory over Czech Lucie Hradecka.